Kerry's trip comes as US President Barack Obama is trying to persuade the US Congress to authorise a limited military strike against Syria for its alleged use of sarin gas against its own people on 21 August.
Kerry is to leave today for the capital of Lithuania, which holds the rotating presidency of the European Union and is hosting a meeting of European Union foreign ministers with whom the US secretary of state will meet on Saturday.
Kerry and EU ministers plan to "discuss the Middle East, including Syria, Egypt, and the ongoing direct, final status negotiations between the Israelis and Palestinians," State Department spokeswoman Jen Psaki said in a statement.
Later on Saturday Kerry will travel to Paris to meet with senior French government officials and, on Sunday, to see representatives of the Arab League "follow-on" committee that is tracking efforts to bring about an Israeli-Palestinian peace agreement.
While Psaki said the purpose of the meeting on Sunday was for Kerry to provide an update on Israeli-Palestinian peace talks, which resumed on 29 July after a nearly three-year hiatus, she said there was "no doubt" Syria would be discussed.
Then Kerry goes to London, where on Monday he will see British officials and meet Abbas, the Palestinian leader. A US official said Kerry would also meet Israeli Prime Minister Benjamin Netanyahu "in the near future" but gave no details.
On Thursday in Vilnius, Lithuanian Minister of Foreign Affairs Linas Linkevičius met with the Foreign Affairs chief Catherine Ashton. The meeting reportedly focused on the European Neighbourhood Policy.
The 6-7 September Gymnich-type informal meeting of EU foreign affairs ministers in Vilnius was reportedly planned to focus on Russia's bid to bloc Ukraine's ambitions to move closer to the European Union. Moreover, Russia increased its pressure on Moldova and convinced Armenia to join the Russia-led Customs Union, instead of concluding a free trade agreement with the EU.
The Kerry visit appears to have eclipsed those issues on the ministerial agenda. According to a communiqué, Linkevičius and Ashton agreed to further coordinate the cooperation in this area between the European External Action Service and Lithuania. The country hosts a summit of the Eastern Partnership on 28-29 November, where an EU-Ukraine Association Agreement is expected to be signed.